Happen to running Windows 7 64bit, with a Wacom Bamboo tablet driver installed (tablet unplugged), using a wireless mouse, mysteriously my mouse does not working well in MS Paint and WLM drawing.
It might cause by recent Windows Update, or some mystery stuff happening background, my mouse start to act weird on MS Paint, where I click and drag (or draw) is actually not the actual drawing happen, the real drawing happen slightly (quite) off the actual clicking point, but it does working well on normal clicking and dragging.
Fixed it by going Control Panel –> Mouse, and click the OK button, it take few second to save and close the mouse properties dialog, and magically it fixed my mouse problem, weird. :S